An implant tablet of disulfiram (DSF) was developed in order to achieve its sustained supply and its release was evaluated in vitro and in vivo. In present work an attempt was made to formulate and evaluate a sustained release implant of Disulfiram and biodegradable polymer Chitosan. The effect of different proportion of polymer Chitosan (26.66, 33.33 and 40.00 % w/w) and Disulfiram on the drug release kinetics was also studied. The prepared implants were evaluated for hardness, thickness and diameter. Invitro drug release of Disulfiram was studied using three different methods, i.e. Vial, Paddle over Disk and Basket. In vivo release was studied by implanting the implants subcutaneously in mice of equal age and weight group. In vivo drug release from Disulfiram Chitosan implant was studied. The in vitro and in vivo release data was also subjected to Zero order, First order, Higuchi and Korsmayer Peppas kinetic treatment.
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